Crop4Clima

Crop 4 clima

An International Team of Biotechnology Experts

Our highly skilled team, with expertise in computational biology, synthetic biology, and molecular genetics, will work together to create climate-resilient rapeseed through a series of trials and analyses that ensure high yield and quality.

Evogene: Decoding biology

Evogene Ltd. (Nasdaq: EVGN, TASE: EVGN) is a computational biology company leveraging big data and artificial intelligence, aiming to revolutionize the development of life-science-based products by utilizing cutting-edge technologies to increase the probability of success while reducing development time and cost. Evogene established three unique tech-engines focused on the discovery and development of products based on one of the following three core components: microbes – MicroBoost AI, small molecules – ChemPass AI, and genetic elements – GeneRator AI.

Evogene uses its tech-engines to develop products through subsidiaries and strategic partnerships. Evogene’s subsidiaries currently utilize the tech-engines to develop human microbiome-based therapeutics (Biomica), ag-biologicals (Lavie Bio), ag-chemicals (AgPlenus), medical cannabis products (Canonic) and castor varieties for the biofuel and other industries (Casterra).

Evogene’s Ag-Seed division has over 15 years of experience discovering and developing biotech-improved crops that increase productivity by improving yield, abiotic stress tolerance, and insect and disease tolerance [control?] for various crops, utilizing Evogene’s GeneRator AI tech-engine.

Expertise

  • Plant biotechnology, molecular biology, physiology, breeding, and genetics for developing agricultural solutions.
  • Computational biology leveraging big data and artificial intelligence. 
  • Product engineering and technology consolidation.
  • Proven record of establishing and scaling technology-based companies in life sciences industries.

Role in the Project

Evogene is the coordinator of the Crop4Clima program, orchestrating the efforts of the partners for the development of climate-resilient rapeseed lines and leading the communication with the European Innovation Council.

In addition, Evogene will produce rapeseed lines harbouring the novel TaCo pathway and test them in standardized field and greenhouse trials in order to validate the improved lines for their potential for increasing grain yields and drought tolerance and in order to characterize the impact of the technology on enhanced CO₂ assimilation.

Moreover, Evogene will establish a commercialization strategy and manage the business and marketing program, including aspects related to future regulatory requirements related to the technology, with the intention of establishing a technology-based company.

Team

  • Basia Vinocur
  • Eyal Ronen
  • Alin Brown
  • Naama Shani
  • Sassi Masliah
Max Planck Institute for Terrestrial Microbiology

The Max Planck Institute for Terrestrial Microbiology, founded in 1991, is a renowned research institute with around 20 research groups. Their research delves into understanding microorganisms at molecular, cellular, and community levels. With a particular emphasis on cellular and community adaptation to environmental changes, they aim to unravel the diversity and function of microorganisms. Their research encompasses vital roles in global matter cycles, greenhouse gas conversion, and impactful interactions with humans, animals, and plants, making microorganisms paramount in shaping life on Earth.

The Biochemistry and Synthetic Metabolism group aims to understand and apply the fundamental design principles of metabolism. They focus on exploring and engineering novel CO₂-converting enzymes to build novel, synthetic photosynthetic pathways. In the last five years, the group has published over 60 articles, several in leading journals, filed more than five patents and was funded over 10 million euros.

Expertise

  • Synthetic-constructive biology
  • Dark metabolism enzymes and pathways
  • Evolutionary molecular mechanism and engineering of CO₂-fixing enzymes
  • Synthetic metabolic pathways and cells

Role in the Project

The Max Planck Institute for Terrestrial Microbiology will provide an analysis platform to characterize the TaCo pathway and optimize its performance in rapeseed. They will employ in vitro and in vivo experiments to quantify enzyme activity, identify bottlenecks, and analyze oil profiles for nutritional value.

Team

  • Tobias J. Erb
  • Daniel Marchal
  • Jan Zarzycki
  • Nelli Pfeifer
  • Ari Satanowski
Agro-Bio Institute (ABI)

The AgroBioInstitute (ABI) was established in 2000 as a successor of the Central Laboratory of Genetic Engineering (CLGE), founded in 1985, later – the Institute of Genetic Engineering (IGE). ABI is the leading research centre in Bulgaria for plant and agro-biotechnologies. With 50 dedicated staff, including researchers and scientists, ABI conducts basic and applied research in cellular, functional and molecular genetics. Their expertise includes plant micropropagation and in vitro regeneration, production of bioactive compounds, physiological and biochemical studies and genetic marker systems.

ABI collaborates with international organizations, manages plant genetic resources and focuses on GMO biosafety, risk assessment and public perception of research. With its well-equipped facilities and highly experienced staff, ABI offers PhD training and has organized numerous scientific events. The successful international collaboration results in high-impact publications and contributions to research in the field.

Expertise

  • Molecular biology, physiology, biochemistry, and biotechnology
  • Characterisation, development, and application of genetic resources and biodiversity
  • Transgenic research
  • Sustainability, food safety, welfare, and responsible science 

Role in the Project

ABI will develop a suitable methodology for integrating and validating the TaCo pathway in rapeseed. They will establish measurement protocols for various physiological and biochemical evaluations to maintain nutritional values and regulatory compliance. Additionally, ABI will assist in validating the technology through greenhouse trials, including stress conditions.

Team

  • Dimitar Djilianov
  • Daniela Moyankova
  • Mariyan Minchev
  • Sonya Ivanova
IN society: Shaping innovation

IN society, established in 2008, specialises in managing innovation for private and public organisations. As a not-for-profit research firm, it conducts studies and analyses of the impact of innovation on society while developing strategies to maximise its benefits. They aim to empower research teams and individuals to convert disruptive technological concepts into innovative products or services. They collaborate with small and medium-sized enterprises, universities, and research centres to nurture ideas from inception to market exploitation.

Expertise

  • Technology transfer from concepts to innovative products/services
  • Start-up and spin-off facilitation
  • Communication, dissemination, and exploitation strategies
  • Stakeholder and public engagement

Role in the Project

IN society will lead open science promotion, stakeholder engagement, co-developer/investor involvement, result dissemination, project visibility, and facilitating translation across all C3 crops while ensuring effective exploitation, dissemination, and communication.

Team

  • Laura Martinelli
  • Mirko Busto
  • Diogo Matias
  • Elisa Beltramini
  • Francesco Pascolo
  • Michela Candotti
  • Paulina Piotrowicz